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Related Experiment Video

Updated: May 20, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Vulvar lymphangioma circumscriptum presenting periodic symptoms.

Arif Kokcu1, Levent Yildiz, Devran Bildircin

  • 1Department of Obstetrics and Gynecology, Ondokuz Mayis University, Medical Faculty, Samsun, Turkey. arifkokcu@yahoo.com

BMJ Case Reports
|July 18, 2012
PubMed
Summary

This study details a rare case of acquired lymphangioma circumscriptum (LC) in the vulva. The condition recurred in new locations shortly after surgical removal, suggesting unique disease behavior.

Related Experiment Videos

Last Updated: May 20, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

  • Gynecology
  • Dermatology
  • Vascular Malformations

Background:

  • Lymphangioma circumscriptum (LC) is a rare benign vascular tumor characterized by clusters of lymphatic cysts.
  • Acquired forms of LC are less common than congenital ones and often lack a clear etiological factor.
  • Vulvar LC is an uncommon presentation, posing diagnostic and management challenges.

Observation:

  • A case of acquired lymphangioma circumscriptum (LC) localized to the right labium majus of the vulva is presented.
  • The patient experienced periodic symptoms for 8 years.
  • Following a right major labiectomy, recurrent symptoms manifested in the contralateral left labium majus and ipsilateral right labium minus within 3 months.

Findings:

  • This represents the first reported case of acquired vulvar LC with this specific pattern of rapid, multifocal recurrence after surgical intervention.
  • The absence of a known etiological factor in this case highlights potential idiopathic pathways for acquired LC.
  • The clinical presentation and rapid recurrence suggest a unique pathophysiology for this vulvar lymphangioma circumscriptum.

Implications:

  • This case underscores the importance of considering acquired LC in the differential diagnosis of vulvar masses with recurrent symptoms.
  • The observed recurrence pattern may necessitate a re-evaluation of surgical management strategies for vulvar LC.
  • Further research into the etiology and behavior of acquired vulvar lymphangioma circumscriptum is warranted to improve patient outcomes.