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Related Concept Videos

Tonsillitis II: Management01:26

Tonsillitis II: Management

This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
Tonsillitis I: Introduction01:30

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Chronic Pharyngitis01:23

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Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

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Related Experiment Video

Updated: May 20, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Tonsillectomy and IgA nephritis.

Claudio Ponticelli1

  • 1Division of Nephrology, Istituto Clinico Humanitas, Rozzano, Milano, Italy. claudio.ponticelli@fastwebnet.it

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|July 18, 2012
PubMed
Summary
This summary is machine-generated.

Tonsillectomy may improve outcomes for patients with IgA nephritis (IgAN), an autoimmune kidney disease. A study suggests tonsillectomy can lead to more remissions and slower kidney function decline in IgAN patients.

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Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
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Published on: October 13, 2023

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Last Updated: May 20, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
05:39

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice

Published on: July 8, 2020

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro
14:18

Dioscin Mediated IgA Nephropathy Alleviation by Inhibiting B Cell Activation In Vivo and Decreasing Galactose-Deficient IgA1 Production In Vitro

Published on: October 13, 2023

Area of Science:

  • Nephrology
  • Immunology
  • Otolaryngology

Background:

  • IgA nephritis (IgAN) is an autoimmune kidney disease causing IgA deposits in the glomerulus.
  • Aberrant IgA1 O-glycans trigger autoantibodies, forming immune complexes that damage the kidneys.
  • Pharyngotonsillitis is linked to IgAN episodes, leading to tonsillectomy use in some regions.

Purpose of the Study:

  • To evaluate the long-term impact of tonsillectomy on IgA nephritis progression.
  • To compare renal function and remission rates in tonsillectomized versus non-tonsillectomized IgAN patients.

Main Methods:

  • A longitudinal retrospective study compared outcomes of IgAN patients who underwent tonsillectomy with those who did not.
  • Analysis focused on remission rates and the slope of glomerular filtration rate (GFR).

Main Results:

  • Tonsillectomized IgAN patients demonstrated a higher number of disease remissions.
  • Patients who had tonsillectomy showed a better GFR slope, indicating slower kidney function decline.
  • These benefits were observed in patients with normal renal function and mild proteinuria.

Conclusions:

  • Tonsillectomy may be a beneficial intervention for preventing renal dysfunction in IgAN patients.
  • The findings suggest tonsillectomy could preserve kidney function in IgAN.
  • Further prospective studies are needed to confirm these promising results due to the retrospective nature and potential confounding factors.