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Effects of heparin on synaptic activity in the hemorrhagic stroke model in vitro

A A Mokrushin1, L I Pavlinova

  • 1I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

Bulletin of Experimental Biology and Medicine
|July 18, 2012
PubMed

We studied the ability of heparin to modify synaptic activity on the original stroke model in vitro. Cultured slices of the brain slices from hypertensive rats were treated with the autoblood clot. Administration of heparin (2 mg/ml) before autoblood treatment had a protective effect on ionotropic glutamatergic and GABAergic receptors, whose activity was inhibited by the blood.

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