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Helicobacter pylori and recurrent abdominal pain in children: is there any relation?

M M H K Mansour1, Kh M Al Hadidi, M A Omar

  • 1Department of Pediatrics, Cairo University, Egypt. fractaledge3@yahoo.com

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|July 19, 2012
PubMed

Insights

Helicobacter pylori (HP) infection is common in children, affecting over 40% of both symptomatic and asymptomatic individuals. This study found no association between HP infection and recurrent abdominal pain (RAP) in children.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Clinical Research

Background:

  • The role of Helicobacter pylori (HP) in recurrent abdominal pain (RAP) and gastrointestinal symptoms remains controversial.
  • A significant debate exists regarding the necessity of testing for and treating HP infections.

Purpose of the Study:

  • To investigate the correlation between HP infection and RAP in children.
  • To examine the association between HP and other gastrointestinal symptoms.

Main Methods:

  • A case-control study was conducted with 244 children aged 2-16 years with RAP (cases) and 122 age/gender-matched asymptomatic children (controls).
  • Exclusion criteria included recent antibiotic or acid-suppressing medication use.
  • HP infection was diagnosed using stool antigen and/or urea breath tests.

Main Results:

  • HP infection was present in 42.6% of cases and 45% of controls.
  • No significant differences in age, sex, nationality, or body weight were observed between groups.
  • In symptomatic children, HP positivity was linked to vomiting, epigastric pain, family history of infection, and iron deficiency anemia.

Conclusions:

  • Helicobacter pylori infection is prevalent in over 40% of both symptomatic and asymptomatic children.
  • The study found no association between recurrent abdominal pain and HP infection in the pediatric population.
Abstract

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