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Updated: May 20, 2026
06:58
Culturing and Measuring Fetal and Newborn Murine Long Bones
Published on: April 26, 2019
Cross-talk between FGF and other cytokine signalling pathways during endochondral bone development
Min Jin1, Xiaolan Du, Lin Chen
1State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Peoples Republic of China.
Cell Biology International
|July 19, 2012
Summary
Fibroblast growth factor (FGF) and FGF receptor (FGFR) signaling are crucial for bone development. This review explores how FGF signaling interacts with other pathways during skeletal development.
Area of Science:
- Skeletal Biology
- Developmental Biology
- Cell Signaling
Background:
- Fibroblast growth factor (FGF)/FGF receptor (FGFR) signaling is vital for skeletal development.
- This pathway is essential from early limb bud formation through mature bone formation.
- FGF signaling's role spans both endochondral and intramembranous ossification processes.
Purpose of the Study:
- To review the intricate interplay between FGF signaling and other regulatory pathways.
- To highlight the spatial and temporal regulation of FGF signaling during endochondral ossification.
- To provide a comprehensive overview of FGF signaling's integration within the broader skeletal development network.
Main Methods:
- Literature review of existing research on FGF signaling in skeletal development.
- Analysis of studies focusing on the interaction of FGF with other signaling cascades.
- Synthesis of data on the spatiotemporal control of FGF/FGFR activity in bone formation.
Main Results:
- FGF/FGFR signaling is a central regulator, influencing multiple stages of skeletal development.
- Numerous intracellular and extracellular signals modulate FGF pathway activity.
- The integration of FGF signaling with other pathways is critical for precise skeletal patterning and growth.
Conclusions:
- Understanding the crosstalk between FGF and other pathways is key to deciphering skeletal development.
- Precise spatiotemporal regulation of FGF signaling ensures proper bone formation.
- This review consolidates current knowledge on FGF pathway integration in endochondral ossification.
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