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Related Experiment Video

Updated: May 20, 2026

U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index

U-Shaped Horizontal Swimming Technique for Preparing High-Quality Sperm with Low DNA Fragmentation Index

Published on: March 28, 2025

New era in sperm selection for ICSI.

M H Nasr-Esfahani¹, M R Deemeh, M Tavalaee

¹Department of Reproduction and Development, Reproductive Biomedicine Research Center, Royan Institute for Biotechnology, ACECR, Isfahan, Iran. mh.nasr-esfahani@royaninstitute.org

International Journal of Andrology

|July 19, 2012

Summary

This summary is machine-generated.

Selecting sperm based on DNA integrity, not just appearance, improves embryo development after intra-cytoplasmic sperm injection (ICSI). Novel methods enhance success rates by avoiding damaged sperm insemination.

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Published on: January 26, 2024

Area of Science:

Reproductive Biology
Genetics
Assisted Reproductive Technologies

Background:

Sperm DNA damage can lead to failed embryo development after intra-cytoplasmic sperm injection (ICSI).
Traditional sperm selection methods (viability, morphology) do not effectively remove DNA-damaged spermatozoa.
Ensuring sperm DNA integrity is crucial for successful fertilization and embryonic development.

Purpose of the Study:

To review novel sperm selection techniques that identify and exclude DNA-damaged spermatozoa.
To analyze the scientific basis, advantages, and disadvantages of these advanced sperm selection procedures.
To provide insights into improving ICSI outcomes through functional sperm selection.

Main Methods:

Systematic literature search using PubMed and ISI-Web databases.
Inclusion of data from the authors' own research.
Review of scientific literature, publications, and presentations on sperm selection methods.

Main Results:

Novel sperm selection procedures offer improved efficacy over traditional methods in identifying and excluding DNA-damaged sperm.
These advanced techniques aim to reduce the incidence of failed embryo development post-ICSI.
Functional sperm selection is key to enhancing ICSI success rates.

Conclusions:

Functional sperm selection based on DNA integrity is essential for successful ICSI.
Novel sperm selection methods provide a promising alternative to traditional techniques.
Further research and adoption of these methods can significantly improve assisted reproductive technology outcomes.