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Updated: May 20, 2026

Murine Model of CD40-activation of B cells
Published on: March 5, 2010
T-cell-independent antitumor effects of CD40 ligation
Alexander L Rakhmilevich1, Kory L Alderson, Paul M Sondel
1Department of Human Oncology and Paul P. Carbone Comprehensive Cancer Center, University of Wisconsin-Madison, Madison, WI 53705, USA. rakhmil@humonc.wisc.edu
Abstract:
CD40 ligation has been shown to induce antitumor effects in mice and cancer patients. Most of the studies have focused on the ability of an agonistic anti-CD40 mAb to either directly kill CD40-positive tumor cells or activate T-cell immune responses. In this review the authors focus on the ability of CD40 ligation to activate antitumor effector mechanisms of the cells of innate immunity such as macrophages and NK cells.
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