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Updated: May 20, 2026
05:47
Isolation of Murine Lymph Node Stromal Cells
Published on: August 19, 2014
Mesenchymal stromal cells: a key player in 'innate tolerance'?
Francesco Dazzi1, Luciene Lopes, Ling Weng
1Stem Cell Biology, Department of Medicine, Imperial College London, London, UK. f.dazzi@imperial.ac.uk
Immunology
|July 19, 2012
Summary
Mesenchymal stromal cells (MSCs) support tissues and modulate inflammation. Recent findings show MSCs can impair immune cells, including antigen-presenting cells, revealing a new role in immune regulation.
Area of Science:
- Immunology
- Cell Biology
- Tissue Engineering
Background:
- Mesenchymal stromal cells (MSCs) are recognized for their role in supporting parenchymal tissues across organs.
- Emerging research highlights MSCs' significant function in modulating inflammatory responses.
Purpose of the Study:
- To summarize the novel immunomodulatory functions of mesenchymal stromal cells (MSCs).
- To detail the capacity of MSCs to influence immune cell activity, particularly antigen-presenting cells.
Main Methods:
- Literature review of studies investigating MSC-immune cell interactions.
- Analysis of experimental data demonstrating MSC effects on immune cell function.
Main Results:
- MSCs possess potent anti-inflammatory properties.
- MSCs can significantly impair the function of various immune cells, including antigen-presenting cells.
Conclusions:
- Mesenchymal stromal cells (MSCs) play a critical, previously unrecognized role in regulating immune responses.
- The immunomodulatory capacity of MSCs offers potential therapeutic avenues for inflammatory conditions.
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