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Common peroneal neuropathy and cancer
1Prince of Wales Clinical School and Neuroscience Research Australia, University of New South Wales, Sydney, New South Wales, Australia.
Internal Medicine Journal
|July 19, 2012
Summary
Common peroneal neuropathy (CPN) in cancer patients often follows rapid weight loss. This may cause metabolic nerve deficiency, exposing vulnerability, particularly at the fibular head.
Area of Science:
- Neurology
- Oncology
- Neurophysiology
Background:
- Common peroneal neuropathy (CPN) can unexpectedly affect cancer patients.
- The pathophysiology linking cancer, weight loss, and CPN requires clarification.
Purpose of the Study:
- To investigate the clinical and neurophysiological characteristics of CPN in cancer patients.
- To explore the relationship between advanced malignancy, weight loss, and CPN onset.
Main Methods:
- Prospective collection of clinical and neurophysiological data.
- Neurological assessment of 10 oncology patients with new-onset foot weakness.
- Localization of neuropathy using neurophysiological studies.
Main Results:
- CPN occurred in patients with advanced systemic malignancy and significant weight loss.
- Neurophysiological studies identified the fibular head as the site of CPN in 80% of cases.
- Findings suggest rapid weight loss may precipitate CPN in susceptible individuals.
Conclusions:
- Rapid weight loss in cancer patients may lead to CPN.
- A relative metabolic nerve deficiency, exacerbated by anatomical susceptibility, is hypothesized.
- This mechanism may uncover pre-existing subclinical nerve injury.
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