Related Experiment Video
Updated: May 20, 2026
09:38
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
Published on: April 14, 2016
[Pain as adverse drug reaction]
Birgit Böhmdorfer1, Daniel Schaffarzick, Marietta Nagano
1Anstaltsapotheke, Krankenhaus Hietzing mit Neurologischem Zentrum Rosenhügel, Wolkersbergenstrasse 1, 1130, Wien, Österreich. birgit.boehmdorfer@wienkav.at
Wiener Medizinische Wochenschrift (1946)
|July 19, 2012
Summary
This study analyzes pain as a potential adverse drug reaction, examining how drugs influence pain pathways. Understanding drug effects on nociception and antinociception reveals therapeutic dolorigene potential.
Area of Science:
- Pharmacology
- Neuroscience
- Bioinformatics
Context:
- Pain is a complex symptom with diverse manifestations.
- Adverse drug reactions (ADRs) represent a significant clinical challenge.
- Understanding drug-induced pain (dolorigenicity) requires a multidisciplinary approach.
Purpose:
- To analyze pain as a potential adverse drug reaction.
- To investigate the influence of drugs on nociception and antinociception.
- To assess the dolorigene potential of therapeutics within the Austrian drug market.
Summary:
- A multidisciplinary analysis integrating anesthesiology, clinical pharmacy, and bioinformatics was conducted.
- The study explored various pain manifestations and drug classes relevant to the Austrian market.
- An overview was created detailing how drugs modulate neurotransmitters involved in pain and pain relief.
Impact:
- Provides insights into the mechanisms by which drugs can induce or exacerbate pain.
- Facilitates better identification and management of drug-related pain.
- Contributes to safer drug prescribing and development by considering dolorigene potential.
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