General principles for the regeneration of bone and cartilage

For the regeneration of bone and cartilage, mesenchymal stem cells are currently used invitro and in-vivo. For bone, the existence of viable cells, scaffolds, mechanical environment, growth factors and vascularization are of paramount importance. Mesenchymal stem cells can be harvested from the bone marrow using minimally invasive techniques. Centrifugation can increase the number of transplanted cells per volume. The use of cell therapy is under current clinical investigation and the benefit from these systems has to be proven in level I studies. For cartilage, current techniques recruiting stem cells from the subchondral bone have been demonstrated to be nearly as effective as autologous chondrocyte transplantation, requiring less invasive surgery. The efficacy of mesenchymal stem cell concentrates remains to be proven. There is high potential for tissue engineered joint surfaces to become an option for joint surface defects and degeneration.