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Highly pathogenic avian influenza (H5N1) in Myanmar, 2006-2010

Pont Pont Mon1, Jiradej Lapkuntod, Min Thein Maw

  • 1Department of Veterinary Public Health, Chulalongkorn University, Bangkok 10330, Thailand.

Archives of Virology
|July 19, 2012
PubMed

Insights

Highly pathogenic avian influenza (HPAI) virus subtype H5N1 outbreaks in Myanmar between 2007-2010 were analyzed. Phylogenetic and genetic analyses confirmed multiple introductions and HPAI characteristics of these H5N1 viruses.

Area of Science:

  • Veterinary Virology
  • Molecular Epidemiology
  • Infectious Disease Dynamics

Background:

  • Highly pathogenic avian influenza (HPAI) virus subtype H5N1 poses a significant threat to avian populations globally.
  • The first reported outbreak of HPAI (H5N1) in Myanmar occurred in 2006, necessitating further investigation into circulating strains.

Purpose of the Study:

  • To characterize HPAI (H5N1) viruses isolated from Myanmar between 2007 and 2010.
  • To determine the phylogenetic origins and genetic makeup of these viruses.
  • To understand the introduction dynamics of HPAI (H5N1) into Myanmar.

Main Methods:

  • Phylogenetic analysis of viral nucleotide sequences.
  • Genetic characterization of HPAI (H5N1) isolates.
  • Comparative analysis with global HPAI (H5N1) strains.

Main Results:

  • Six HPAI (H5N1) viruses from 2007-2010 and three additional sequences were analyzed.
  • Myanmar HPAI (H5N1) viruses belonged to clades 7, 2.3.2, and 2.3.4.
  • Genetic analysis confirmed the highly pathogenic nature of the studied viruses.

Conclusions:

  • The HPAI (H5N1) viruses in Myanmar originated from multiple independent introductions.
  • Ongoing surveillance and characterization are crucial for understanding HPAI (H5N1) evolution and spread in the region.

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