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Related Concept Videos

Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Reactions02:06

Allergic Reactions

Overview
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...

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Updated: May 20, 2026

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

[Pulmonary allergic reactions].

A R Koczulla1, B Beutel, T Greulich

  • 1Klinik für Innere Medizin, Schwerpunkt Pneumologie, Philipps-Universität Marburg, Baldingerstr. 1, 35043, Marburg, Deutschland. koczulla@med.uni-marburg.de

Der Internist
|July 19, 2012
PubMed
Summary
This summary is machine-generated.

Allergic lung diseases impact airways, lung tissue, and vessels, including allergic asthma and hypersensitivity pneumonitis. Emerging therapies target specific disease mechanisms for better treatment outcomes.

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A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
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Published on: April 13, 2010

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Last Updated: May 20, 2026

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
08:58

Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography

Published on: July 10, 2018

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice
09:58

A Reversible, Non-invasive Method for Airway Resistance Measurements and Bronchoalveolar Lavage Fluid Sampling in Mice

Published on: April 13, 2010

Area of Science:

  • Pulmonology
  • Immunology
  • Allergy

Context:

  • Allergic lung diseases encompass conditions affecting airways, parenchyma, and pulmonary vessels.
  • Key examples include allergic asthma, hypersensitivity pneumonitis, bronchopulmonary aspergillosis, and Churg-Strauss syndrome.

Purpose:

  • To review the diverse range of allergic lung diseases.
  • To highlight the varying allergic reaction types and pathophysiological consequences.
  • To discuss novel therapeutic strategies targeting specific pathogenetic mechanisms.

Summary:

  • Allergic lung diseases present heterogeneously, affecting different lung compartments.
  • The clinical presentation and underlying immune responses differ significantly among these conditions.
  • Recent advancements provide insights into disease pathogenesis, guiding the development of targeted therapies.

Impact:

  • Improved understanding of allergic lung disease mechanisms.
  • Potential for more precise and effective therapeutic interventions.
  • Advancement in the management of chronic respiratory allergic conditions.