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The MG-QOL15 Japanese version: validation and associations with clinical factors
Masayuki Masuda1, Kimiaki Utsugisawa, Shigeaki Suzuki
1Department of Neurology, Tokyo Medical University, Tokyo, Japan.
Introduction:
Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG.
Methods:
We evaluated 327 consecutive patients with MG seen at six neurological centers. All patients completed the Japanese version of the MG-QOL15 (MG-QOL15-J), the Beck Depression Inventory-second edition (BDI-II), and a generic health-related QOL questionnaire, the SF-36. Disease severity was determined according to the Myasthenia Gravis Foundation of America (MGFA) quantitative MG score and the MG composite.
Results:
The MG-QOL15-J exhibited adequate internal reliability, test-retest repeatability, and concurrent validity with SF-36, disease severity, and known-patient groups categorized by MGFA post-intervention status. Multivariate analysis revealed severity, dose of oral corticosteroids, and BDI-II as independent factors negatively affecting QOL.
Conclusion:
The MG-QOL15-J is anticipated to be a valuable clinical measure of QOL in Japanese patients with MG.
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