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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...

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Related Experiment Video

Updated: May 20, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Osteoporosis and polypharmacy.

M Gosch1, M Jeske, C Kammerlander

  • 1Abt. für Innere Medizin und Akutgeriatrie, Landeskrankenhaus Hochzirl, Hochzirl 1, 6170, Zirl, Österreich. markus.gosch@tilak.at

Zeitschrift Fur Gerontologie Und Geriatrie
|July 19, 2012
PubMed
Summary
This summary is machine-generated.

Drug interactions with osteoporosis medications are minimal in elderly patients. However, those with multiple medications (polypharmacy) face higher fracture risks and warrant osteoporosis treatment.

Related Experiment Videos

Last Updated: May 20, 2026

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice
07:20

Studies on the Anti-Inflammatory Effect of Xiaoyao Pills in The Treatment of Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

Area of Science:

  • Geriatric Medicine
  • Pharmacology
  • Bone Metabolism

Background:

  • Osteoporosis is prevalent in the elderly, leading to significant health consequences and socioeconomic costs.
  • Low treatment rates for osteoporosis persist, often attributed to polypharmacy concerns like drug interactions and patient compliance.
  • Numerous medications can directly or indirectly influence bone metabolism.

Purpose of the Study:

  • To evaluate the risk of drug interactions between common anti-osteoporotic therapies and other medications frequently used by elderly patients.
  • To assess the impact of these interactions on bone metabolism and fracture risk in this demographic.

Main Methods:

  • Review of existing literature on drug interactions concerning oral and parenteral bisphosphonates, raloxifene, strontium ranelate, teriparatide, and denosumab.
  • Analysis of the effects of these interactions on bone metabolism and fracture risk in elderly populations.

Main Results:

  • The number and clinical significance of drug interactions involving common anti-osteoporotic drugs are generally small and considered clinically irrelevant.
  • Patients on polypharmacy exhibit an elevated risk of fractures, irrespective of direct drug interactions with osteoporosis treatments.

Conclusions:

  • Concerns regarding drug interactions should not deter the indicated treatment of osteoporosis in elderly patients, even those with polypharmacy.
  • Elderly patients with polypharmacy are at increased fracture risk and should be considered for osteoporosis treatment if indicated.