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Related Concept Videos

Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

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Graves' Disease I: Introduction

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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

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Related Experiment Video

Updated: May 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

[Scleromyxedema. A chronic progressive systemic disease].

A Kreuter1, M Stücker, A G A Kolios

  • 1Klinik für Dermatologie, Venerologie und Allergologie, Ruhr-Universität Bochum im St. Josef Hospital, Gudrunstr. 56, 44791, Bochum, Deutschland. A.Kreuter@derma.de

Zeitschrift Fur Rheumatologie
|July 19, 2012
PubMed
Summary

Scleromyxedema is a rare multisystemic disease often linked to monoclonal gammopathy. Treatments show limited efficacy, with frequent recurrences observed in patients.

Related Experiment Videos

Last Updated: May 20, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Dermatology
  • Internal Medicine

Background:

  • Scleromyxedema is a rare connective tissue disease.
  • It frequently affects multiple internal organs alongside the skin.
  • Monoclonal gammopathy is a near-universal comorbidity.

Observation:

  • This study analyzed four patients with scleromyxedema.
  • Patients underwent comprehensive serological and physical examinations.
  • The mean age was 51, with three women and one man.

Findings:

  • All patients had monoclonal gammopathy (IgG lambda or IgG kappa).
  • Internal organ involvement included lung fibrosis, myositis, arthritis, polyneuropathy, and esophageal hypomotility.
  • Effective treatments included dexamethasone-pulse, IVIG, and bortezomib, but all patients experienced recurrences.

Implications:

  • Scleromyxedema is a rare, multisystemic disorder requiring thorough evaluation.
  • Treatment responses are often suboptimal, with high recurrence rates.
  • Further research into effective, long-term management strategies is warranted.