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Updated: May 20, 2026

Biotinylated Cell-penetrating Peptides to Study Intracellular Protein-protein Interactions
Published on: December 20, 2017
Cell-penetrating peptides as delivery vehicles for a protein-targeted terbium complex
Shabnam Mohandessi1, Megha Rajendran, Darren Magda
1Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA.
Abstract:
Release after transmission: Arginine-rich, cell-penetrating peptides (CPPs) mediate cytoplasmic delivery of trimethoprim (TMP)-terbium complex conjugates and selective, intracellular labeling of E. coli dihydrofolate reductase (eDHFR) fusion proteins. A disulfide bond linking CPP and cargo is reduced following uptake. CPP conjugation can be used to deliver otherwise cell-impermeable, ligand-fluorophore conjugates.
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