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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Radiation Planning Assistant - A Web-based Tool to Support High-quality Radiotherapy in Clinics with Limited Resources
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Active home-based cancer treatment.

Sebastiano Bordonaro1, Fabio Raiti, Annamaria Di Mari

  • 1UOC Medical Oncology, RAO, ASP 8 Siracusa, Italy.

Journal of Multidisciplinary Healthcare
|July 19, 2012
PubMed
Summary

Active home-based cancer care improves patient quality of life and adherence to oral chemotherapy. This model reduces hospital visits and caregiver burden, benefiting elderly and homebound patients.

Keywords:
cancercompliancehome-basedquality of lifetreatment

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Area of Science:

  • Oncology
  • Health Services Research

Background:

  • Chronic cancer treatment necessitates continuous facility access, posing significant patient and caregiver burdens.
  • Oral chemotherapy adherence can be challenging, particularly for elderly patients, due to compliance issues.
  • Home-based care models offer a potential solution to improve treatment delivery and patient outcomes.

Purpose of the Study:

  • To evaluate the feasibility and impact of an active home-based oral chemotherapy program.
  • To assess patient quality of life and adherence to oral cancer therapies in a home setting.
  • To determine the effect of home care on healthcare facility utilization and caregiver support.

Main Methods:

  • A pilot study involving 30 cancer patients receiving oral therapies (capecitabine, vinorelbine, imatinib, etc.) at home.
  • Care provided by an experienced oncology doctor and two nurses, utilizing clinical diaries and the EORTC QLQ-C30 questionnaire.
  • Data collection focused on home visits, hospital visits, caregiver support needs, and patient-reported treatment acceptability.

Main Results:

  • A 98.1% reduction in cancer facility access was observed.
  • Improved patient quality of life, indicated by increased EORTC QLQ-C30 scores.
  • Enhanced adherence to oral treatment due to controlled drug administration outside the hospital.
  • Successful treatment of patients with limited access to care (78% were elderly, disabled, or required caregivers).

Conclusions:

  • Active home care significantly enhances quality of life and adherence to oral cancer therapy.
  • The model reduces hospital visits, leading to decreased work hours lost by caregivers.
  • Nursing staff effectively managed the service, with minimal physician involvement required.