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Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila
09:09

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Published on: January 13, 2014

Adaptive temperature compensation in circadian oscillations.

Paul François1, Nicolas Despierre, Eric D Siggia

  • 1Ernest Rutherford Physics Building, McGill University, Montreal, Quebec, Canada. paulf@physics.mcgill.ca

Plos Computational Biology
|July 19, 2012
PubMed
Summary

Circadian clocks maintain a stable period despite temperature changes through adaptive mechanisms, not just distributed compensation. This new model explains clock properties and offers insights into biological timekeeping.

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Last Updated: May 20, 2026

Design and Analysis of Temperature Preference Behavior and its Circadian Rhythm in Drosophila
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Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
06:53

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures

Published on: November 11, 2016

Area of Science:

  • Chronobiology
  • Systems Biology
  • Molecular Biology

Background:

  • Circadian oscillators exhibit temperature-independent periods and entrainment, key features of biological clocks.
  • Existing models of distributed temperature compensation struggle to explain clock mutants and temperature-dependent variations in clock protein concentrations and phase response curves (PRCs).

Purpose of the Study:

  • To propose and investigate an alternative class of models for circadian temperature compensation.
  • To explain how fixed period and entrainment properties can arise from an underlying adaptive system that buffers temperature fluctuations.

Main Methods:

  • Development of a theoretical framework for adaptive temperature compensation models.
  • Analysis of model properties, including temperature independence of PRCs and orbital extrema.
  • Exploration of evolutionary optimization of gene networks for phase anticipation as a mechanism.

Main Results:

  • The proposed adaptive models exhibit temperature-independent PRCs and orbital extrema, aligning with experimental observations.
  • These models are readily evolved through local optimization strategies focused on phase anticipation.
  • A standard Goodwin model realization demonstrates adaptive, rather than distributed, temperature compensation characteristics.

Conclusions:

  • Adaptive systems provide a more robust framework for understanding circadian temperature compensation than distributed models.
  • Temperature-independent PRCs and orbital properties are hallmarks of these adaptive circadian clock models.
  • Phase anticipation serves as a key evolutionary driver for developing robust, temperature-compensated circadian clocks.