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Updated: May 20, 2026
09:24
3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
Published on: September 13, 2018
Increased cyclin-dependent kinase 6 expression in bladder cancer.
Gang Wang1, Lingyan Zheng, Zhijian Yu
1Division of Urology, The First Hangzhou People Hospital, Hangzhou 310006.
Oncology Letters
|July 19, 2012
Summary
Increased cyclin-dependent kinase 6 (Cdk6) expression is linked to invasive bladder cancer development. This finding suggests Cdk6 may serve as a potential biomarker for detecting bladder cancer progression.
Area of Science:
- Oncology
- Cell Biology
Background:
- Cyclin-dependent kinase 6 (Cdk6) regulates the cell cycle.
- Aberrant Cdk6 expression is implicated in various cancers.
Purpose of the Study:
- To investigate the role of Cdk6 in bladder cancer development.
- To analyze Cdk6 expression in bladder cancer tissues and adjacent tissues.
Main Methods:
- Immunohistochemistry assay was used to examine Cdk6 expression.
- 31 bladder cancer cases and 29 adjacent tissues were analyzed.
- Correlation between Cdk6 expression and clinical characteristics was assessed.
Main Results:
- Cytoplasmic and nuclear Cdk6 levels were significantly elevated in invasive bladder cancer compared to adjacent tissues (P=0.005 and P<0.001).
- No significant difference in Cdk6 expression was observed in non-invasive superficial bladder cancer.
- Cdk6 expression correlated with bladder cancer stage (P=0.026 and P=0.006).
Conclusions:
- Increased Cdk6 expression is associated with bladder cancer development.
- Cdk6 may function as a biomarker for bladder cancer.
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