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Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice
Published on: February 10, 2018
Hepatoprotective effects of immobilized granulocyte colony-stimulating factor and hyaluronidase preparation and their
A M Dygai1, V V Zhdanov, G N Zyuzkov
1Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. zw@pharm.tsu.ru
Abstract:
High hepatoprotective activity of granulocytic CSF and hyaluronidase immobilized using electron-beam immobilization technology was demonstrated on the model of CCl(4)-induced hepatitis: the preparations produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects developed against the background of stimulation of bone marrow multipotent precursor cells and their mobilization into circulation accompanied by an increase in the content of parenchymatous progenitor cells in the liver. The most pronounced positive effect was observed in combined treatment with the test preparations.
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