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Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

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Related Experiment Video

Updated: May 20, 2026

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Ookluc: A Plasmodium berghei Line for Identifying Transmission-blocking Compounds

Published on: July 11, 2025

Emerging drugs for malaria.

Serena Tschan¹, Peter G Kremsner, Benjamin Mordmüller

¹Institute of Tropical Medicine, Wilhelmstrasse 27, 72074 Tübingen, Germany. benjamin.mordmueller@uni-tuebingen.de

Expert Opinion on Emerging Drugs

|July 20, 2012

Summary

This summary is machine-generated.

New malaria drugs are urgently needed as drug resistance is a growing problem. Research is focusing on non-artemisinin candidates, but new therapeutic principles are essential for severe malaria treatment.

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Area of Science:

Infectious Diseases
Tropical Medicine
Pharmacology

Background:

Malaria causes approximately 655,000 deaths annually, predominantly affecting children in Sub-Saharan Africa.
Plasmodium falciparum, the causative agent of severe malaria, exhibits widespread resistance to existing antimalarial drugs.
There is an urgent need for novel antimalarial drugs with distinct mechanisms of action.

Purpose of the Study:

To review non-artemisinin drug candidates for malaria currently in late-stage clinical trials.
To assess the progress and challenges in developing new treatments for malaria.

Main Methods:

A comprehensive review of published data on non-artemisinin antimalarial drug candidates.
Focus on compounds in pre-registration clinical trials up to December 2011.

Main Results:

Several promising non-artemisinin compounds are undergoing clinical evaluation.
The review covers drug candidates in advanced stages of development.

Conclusions:

Despite promising candidates, a significant gap remains in treatments for severe malaria.
The current reliance on artemisinin-based combination therapy for uncomplicated malaria is noted.
Future research must prioritize the discovery of entirely new antimalarial therapeutic principles.