Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Entropy and Solvation02:05

Entropy and Solvation

The process of surrounding a solute with solvent is called solvation. It involves evenly distributing the solute within the solvent. The rule of thumb for determining a solvent for a given compound is that like dissolves like. A good solvent has molecular characteristics similar to those of the compound to be dissolved. For example, polar solutions dissolve polar solutes, and apolar solvents dissolve apolar solutes. A polar solvent is a solvent that has a high dielectric constant (ϵ ≥ 15); an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular switches meet multivalency: Antimicrobial activity of multimeric peptide assemblies from the pneumococcal LytA autolysin.

International journal of biological macromolecules·2026
Same author

Solvent-Induced Stereomutation in Supramolecular Assemblies Explained by Hansen Solubility Parameters.

Journal of the American Chemical Society·2026
Same author

Author Correction: Mapping in situ the assembly and dynamics in aqueous supramolecular polymers.

Nature communications·2026
Same author

Stable Protein-Based G-Quadruplex-Derived Supramolecular Bioinks as Tunable ECM-Mimetic Constructs Assembled by Combining Non-Covalent and Covalent Strategies.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

The Emergence of Chirality in Time and Space: Transient Asymmetry in Supramolecular Polymers Triggered by Visible Light.

Journal of the American Chemical Society·2026
Same author

A microfluidic method for controlled generation and trapping of membraneless water-in-water droplets.

Lab on a chip·2026
Same journal

Switching Site Selectivity in Alkoxyamine Hydration: From Lone-Pair Direction to Solvent Network Dominance.

Journal of the American Chemical Society·2026
Same journal

A Topotactic Leap: 2D Layers to 3D Large-Pore Zeolite.

Journal of the American Chemical Society·2026
Same journal

Enhanced Hydrogen Evolution over Single-Atom Catalysts via Electrostatic Polarization in Contact-electro-catalysis.

Journal of the American Chemical Society·2026
Same journal

Tumor Acidity-Activatable Ionizable Lipid Nanoparticles for Selective Oncolytic Therapy.

Journal of the American Chemical Society·2026
Same journal

Alternating Magnetic Field Promotes Ammonia Cracking by Disrupting the Sabatier Limitation of Ruthenium Catalytic Species.

Journal of the American Chemical Society·2026
Same journal

Bulk Ferromagnetic Icosahedral Quasicrystals without Rapid Quenching.

Journal of the American Chemical Society·2026
See all related articles

Related Experiment Video

Updated: May 20, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

Controlling chemical self-assembly by solvent-dependent dynamics.

Peter A Korevaar1, Charley Schaefer, Tom F A de Greef

  • 1Institute for Complex Molecular Systems and Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology, P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.

Journal of the American Chemical Society
|July 20, 2012
PubMed
Summary
This summary is machine-generated.

The solvent ratio critically impacts supramolecular polymer stability and dynamics. Cooperative assembly shows abrupt disassembly, while non-cooperative systems exhibit gradual changes, revealing key insights into self-assembly processes.

More Related Videos

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Area of Science:

  • Supramolecular chemistry
  • Polymer science
  • Physical chemistry

Background:

  • Supramolecular polymers self-assemble through non-covalent interactions.
  • Solvent quality significantly influences polymer stability and disassembly.
  • Understanding solvent effects is crucial for controlling self-assembly dynamics.

Purpose of the Study:

  • To investigate the influence of good/poor solvent ratios on supramolecular polymer stability and dynamics.
  • To elucidate the role of assembly mechanisms (cooperative vs. isodesmic) in solvent-induced disassembly.
  • To develop a model explaining the observed kinetic behaviors.

Main Methods:

  • Combination of experimental techniques and molecular simulations.
  • Systematic variation of good/poor solvent ratios.
  • Kinetic nucleation-elongation modeling.

Main Results:

  • Cooperative assemblies exhibit complete disassembly at a critical solvent ratio.
  • Isodesmic systems show gradual disassembly profiles.
  • A minimum depolymerization rate was observed at a critical solvent ratio, analogous to protein unfolding.
  • Cooperativity plays a key role in the minimum polymerization/depolymerization rates.

Conclusions:

  • The good/poor solvent ratio is a critical parameter controlling supramolecular polymer stability and disassembly.
  • Assembly mechanism (cooperativity) dictates the disassembly pathway.
  • The findings provide insights into solution-based processing and self-assembly dynamics.