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Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
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Xerostomia: a day and night difference.

Tim Dijkema1, Cornelis P J Raaijmakers, Pètra M Braam

  • 1Department of Radiotherapy, University Medical Center Utrecht, The Netherlands. T.Dijkema@umcutrecht.nl

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|July 20, 2012
PubMed
Summary
This summary is machine-generated.

Nighttime dry mouth is common after head-and-neck cancer radiation, linked to submandibular gland dysfunction. Sparing both parotid and submandibular glands may improve patient xerostomia outcomes.

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Area of Science:

  • Oncology
  • Radiotherapy
  • Salivary Gland Physiology

Background:

  • Head-and-neck cancer (HNC) patients often experience xerostomia (dry mouth) after radiotherapy (RT).
  • Patient-reported symptoms of xerostomia may differ between daytime and nighttime.
  • Objective measurement of salivary gland function is crucial for understanding xerostomia.

Purpose of the Study:

  • To compare patient-reported xerostomia (daytime and nighttime) with objective parotid and submandibular gland function.
  • To investigate the relationship between salivary gland function and xerostomia severity in HNC patients post-RT.

Main Methods:

  • A cohort of 138 HNC patients underwent objective parotid (PF) and submandibular (SMF) gland function measurements.
  • Patients completed a xerostomia questionnaire (XQ) assessing daytime (XD) and nighttime (XN) dry mouth at multiple time points post-RT.
  • No specific effort was made to spare submandibular glands during RT.

Main Results:

  • Submandibular gland function (SMF) was significantly worse in patients with severe xerostomia (grade 4-5) at all time points post-RT.
  • Parotid function (PF) was significantly worse only at 6 weeks post-RT in severe xerostomia patients.
  • SMF was the primary factor associated with nighttime xerostomia (XN), while PF influenced daytime xerostomia (XD).

Conclusions:

  • Differentiating between daytime and nighttime xerostomia is essential for research and clinical practice.
  • Nighttime dry mouth is a frequent issue post-RT for HNC, primarily due to submandibular gland dysfunction.
  • Sparing both parotid and submandibular glands may improve patient-reported xerostomia after HNC treatment.