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Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence
10:52

Closure of a Patent Foramen Ovale (PFO): An Intervention Sequence

Published on: December 23, 2022

Cryptogenic stroke and patent foramen ovale

Cheryl Jaigobin

    Continuum (Minneapolis, Minn.)
    |July 20, 2012
    PubMed

    Insights

    For cryptogenic stroke patients with a patent foramen ovale, both medical therapy and device closure are effective stroke prevention options. The best choice depends on individual patient risks, benefits, and adherence.

    Area of Science:

    • Cardiology
    • Neurology
    • Medical Devices

    Background:

    • Cryptogenic stroke affects patients with a patent foramen ovale (PFO).
    • PFOs are a potential source of paradoxical embolism causing stroke.
    • Current stroke prevention strategies include medical therapy and device closure.

    Purpose of the Study:

    • To compare the efficacy of medical therapy versus percutaneous device closure for stroke prevention in patients with cryptogenic stroke and PFO.
    • To inform clinical decision-making regarding stroke prevention strategies.

    Main Methods:

    • Review of the only completed randomized controlled trial comparing medical therapy and PFO device closure.
    • Analysis of patient outcomes based on treatment received.

    Main Results:

    • No significant difference in outcomes was observed between medical therapy and percutaneous device closure.
    • Both treatment strategies are considered viable options for stroke prevention in this patient population.

    Conclusions:

    • The choice between medical therapy and PFO device closure should be individualized.
    • Consideration of patient-specific risks, benefits, and anticipated adherence is crucial.
    • Clinical trial participation remains an alternative option for eligible patients.

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