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Updated: May 20, 2026
09:39
Establishing a Mouse Model of a Pure Small Fiber Neuropathy with the Ultrapotent Agonist of Transient Receptor Potential Vanilloid Type 1
Published on: February 13, 2018
Clinical approach to peripheral neuropathy: anatomic localization and diagnostic testing
Adina R Alport1, Howard W Sander
1Weill Cornell Medical College, New York, New York, USA.
Continuum (Minneapolis, Minn.)
|July 20, 2012
Summary
A clinical approach to peripheral neuropathy, focusing on anatomic localization and diagnostic tests, is presented. Advances in small fiber neuropathy evaluation and genetic causes are highlighted.
Area of Science:
- Neurology
- Clinical Medicine
Background:
- Peripheral neuropathy evaluation requires a systematic approach.
- Understanding the anatomic localization is key to diagnosis.
Observation:
- History and physical examination are paramount.
- Temporal profile, heredity, and anatomic classification guide diagnosis.
- Anatomic classification includes fiber type, affected nerve portion, and distribution.
Findings:
- Recent advances include small fiber neuropathy evaluation and genetic causes.
- Diagnostic tools encompass serologic tests, CSF analysis, electrodiagnostics, and biopsies.
Implications:
- This systematic approach aids in differential diagnosis of peripheral neuropathies.
- Accurate characterization improves patient management and treatment strategies.
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