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On the Y-chromosome haplogroup C3c classification
Boris A Malyarchuk1, Miroslava Derenko, Galina Denisova
1Genetics Laboratory, Institute of Biological Problems of the North, Russian Academy of Sciences, Magadan, Russia. malyarchuk@ibpn.ru
Journal of Human Genetics
|July 20, 2012
Summary
Y-chromosome haplogroup C3c classification ambiguities were resolved by analyzing key genetic markers in Northern Asian populations. This research clarifies the distinct genetic lineages within haplogroup C3c and its Siberian branches.
Area of Science:
- Population Genetics
- Human Evolutionary Studies
- Y-chromosome Analysis
Background:
- Y-chromosome haplogroup C3c is prevalent in Northern Asian populations, but its classification presents ambiguities.
- Previous studies have not fully resolved the phylogenetic relationships within C3c, necessitating further genetic marker analysis.
Purpose of the Study:
- To clarify the classification of Y-chromosome haplogroup C3c by analyzing specific defining markers.
- To differentiate between C3c, C3c1, and C3c* subhaplogroups using M48, M77, and M86 markers.
Main Methods:
- Analysis of Y-chromosome haplogroup-defining markers M48, M77, and M86.
- Genotyping of individuals belonging to haplogroup C3-M217 from Siberia, Eastern Asia, and Eastern Europe.
Main Results:
- Haplogroup C3c is defined by the derived state at marker M48.
- Subhaplogroup C3c1 is characterized by derived states at both M77 and M86.
- Subhaplogroup C3c* is identified by the derived state at M48 alone, found in Siberian populations like Koryaks, Evens, Evenks, and Yukaghirs.
Conclusions:
- The study provides a refined classification for Y-chromosome haplogroup C3c and its subhaplogroups.
- Subhaplogroup C3c* represents a potentially ancient Neolithic Siberian lineage, with an estimated age of 4.5 ± 2.4 thousand years.
- This genetic analysis contributes to understanding the peopling of Northern Asia and population history.
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