Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Alterations in Muscle Tone ll01:12

Alterations in Muscle Tone ll

Alterations in muscle tone are common manifestations of neurological disorders and reflect dysfunction within different nervous system regions. Spasticity, paratonia, and dystonia represent distinct forms of hypertonia, each with unique mechanisms, clinical features, and diagnostic importance.CharacteristicsSpasticity happens from upper motor neuron lesions and is characterized by velocity-dependent resistance to passive movement. Clinical features include:Exaggerated deep tendon reflexesClonus...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Facial Expression Metrics as Digital Biomarkers of Neurologic Disease.

Neurology open access·2026
Same author

Voice and Speech in Deep Brain Stimulation in Dystonia: A Retrospective Study, Systematic Review, and Meta-Analysis.

Movement disorders : official journal of the Movement Disorder Society·2026
Same author

Longevity Factor Klotho and Resistance to Cognitive Deficits in Individuals with Parkinson's Disease and in an α-Synuclein Mouse Model.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same author

Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.

medRxiv : the preprint server for health sciences·2026
Same author

Test-retest reliability of resting-state functional magnetic resonance imaging during deep brain stimulation for Parkinson's disease.

NeuroImage. Clinical·2026
Same author

10-year clinical outcomes of subthalamic nucleus versus pallidal deep brain stimulation for Parkinson's disease: VA/NINDS CSP #468F.

Frontiers in neurology·2026

Related Experiment Video

Updated: May 20, 2026

Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test
04:06

Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test

Published on: January 12, 2024

Overview of common movement disorders.

Jill L Ostrem, Nicholas B Galifianakis

    Continuum (Minneapolis, Minn.)
    |July 20, 2012
    PubMed
    Summary

    This chapter reviews Parkinson disease, essential tremor, dystonia, and spasticity, common movement disorders affecting the basal ganglia. It details their demographics, clinical features, diagnosis, natural history, and management strategies.

    Area of Science:

    • Neurology
    • Neuroscience

    Background:

    • Movement disorders encompass hypokinetic and hyperkinetic conditions stemming from basal ganglia dysfunction.
    • Commonly encountered diagnoses include Parkinson disease, essential tremor, dystonia, and spasticity.

    Purpose of the Study:

    • To provide a comprehensive overview of four prevalent movement disorders.
    • To detail the demographics, clinical characteristics, diagnostic criteria, natural history, and management of these conditions.

    Main Methods:

    • Review of existing literature and clinical data.
    • Synthesis of information on Parkinson disease, essential tremor, dystonia, and spasticity.

    Main Results:

    • These disorders exhibit significant variability in age of onset, affected areas, and severity.

    More Related Videos

    Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
    05:52

    Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

    Published on: November 21, 2013

    Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
    10:28

    Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

    Published on: July 24, 2019

    Related Experiment Videos

    Last Updated: May 20, 2026

    Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test
    04:06

    Setup for the Quantitative Assessment of Motion and Muscle Activity During a Virtual Modified Box and Block Test

    Published on: January 12, 2024

    Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis
    05:52

    Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

    Published on: November 21, 2013

    Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
    10:28

    Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

    Published on: July 24, 2019

  • Each disorder presents unique diagnostic challenges and management approaches.
  • Conclusions:

    • Understanding the distinct features of Parkinson disease, essential tremor, dystonia, and spasticity is crucial for accurate diagnosis and effective treatment.
    • Further specialized chapters will delve into Parkinson disease management and deep brain stimulation.