Related Experiment Videos
Synthesis and anticonvulsant properties of some arylsuccinate methylpyridylimides
A Zejc1, J Obniska, M Wilimowski
1Department of Pharmaceutical Chemistry, Medical Academy, Kraków, Poland.
Polish Journal of Pharmacology and Pharmacy
|January 1, 1990
Abstract:
In reaction of alpha-phenyl, alpha-p-chlorophenyl and alpha-m-chlorophenylsuccinic acid with various aminopyridines, N-pyridyl-substituted succinimides (compounds 1-14) were obtained. These compounds were investigated for their CNS activity. Compounds 1, 2, 5, 6 and 7 displayed anticonvulsant properties in the maximum electroshock test. Compounds 5 and 6 were also active in the pentetrazole test.