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Overcoming the funding challenge: the cost of randomized controlled trials in the next decade
Benjamin J Shore1, Adam Y Nasreddine, Mininder S Kocher
1Department of Orthopedic Surgery, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
Abstract:
Randomized controlled trials (RCTs) represent the gold standard of evidence-based medicine. However, over the last several decades, the cost associated with conducting RCTs has increased dramatically. Several factors contribute to higher costs associated with clinical trials. This paper describes important barriers to conducting surgical RCTs, identifies funding sources available to finance RCTs, and suggests strategies to maintain cost-efficient study practices as we move into the next decade.
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