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Updated: May 20, 2026
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The Visual Colorimetric Detection of Multi-nucleotide Polymorphisms on a Pneumatic Droplet Manipulation Platform
Published on: September 27, 2016
A lateral flow biosensor for detection of single nucleotide polymorphism by circular strand displacement reaction
Zhuo Xiao1, Puchang Lie, Zhiyuan Fang
1South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510663, China.
Chemical Communications (Cambridge, England)
|July 20, 2012
Abstract:
A lateral flow biosensor for detection of single nucleotide polymorphism based on circular strand displacement reaction (CSDPR) has been developed. Taking advantage of high fidelity of T4 DNA ligase, signal amplification by CSDPR, and the optical properties of gold nanoparticles, this assay has reached a detection limit of 0.01 fM.
