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Related Concept Videos

Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and microglia. Abnormal...
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual.
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...

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Related Experiment Video

Updated: May 20, 2026

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
04:41

Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration

Published on: January 9, 2020

Genetics of dementia.

Claudia Padilla, Richard S Isaacson

    Continuum (Minneapolis, Minn.)
    |July 20, 2012
    PubMed
    Summary

    Genetic factors significantly contribute to adult-onset dementias, influencing various presentations. This review covers key genetic risks and discusses implications for genetic testing and pharmacogenomics in clinical settings.

    Area of Science:

    • Neurology
    • Genetics
    • Pharmacogenomics

    Background:

    • Neurodegenerative adult-onset dementias are complex, multifactorial conditions.
    • Etiologies include environmental, genetic, or combined factors.
    • Genetic causes can lead to diverse clinical phenotypes.

    Purpose of the Study:

    • To review genetic risk factors for common dementias.
    • To discuss practical implications of genetic testing.
    • To explore pharmacogenomic considerations in clinical practice.

    Main Methods:

    • Literature review of genetic risk factors for dementia.
    • Analysis of genetic testing utility.
    • Review of pharmacogenomic data.

    Main Results:

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    Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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    Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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    • Identified various genetic risk factors contributing to dementia.
    • Highlighted the importance of genetic testing in diagnosis and management.
    • Discussed the role of pharmacogenomics in personalized treatment.

    Conclusions:

    • Genetic factors play a crucial role in adult-onset dementias.
    • Genetic testing offers valuable insights for clinical practice.
    • Pharmacogenomic approaches can optimize dementia treatment strategies.