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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

The isolated prolonged PTT.

Oxana Tcherniantchouk¹, Michael Laposata, Marisa B Marques

¹Department of Pathology, Cedars-Sinai Hospital, Los Angeles, California, USA.

American Journal of Hematology

|July 20, 2012

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Choosing the right lab tests for abnormal results like prolonged activated partial thromboplastin time (PTT) is crucial. This study presents an algorithm to improve diagnostic accuracy and reduce errors in common clinical scenarios.

Area of Science:

Clinical diagnostics
Laboratory medicine
Medical decision-making

Background:

Selecting appropriate laboratory tests for abnormal results is challenging, leading to diagnostic delays and increased healthcare costs.
Errors in test selection can result in significant, potentially life-threatening clinical mistakes.
Common laboratory abnormalities, such as prolonged activated partial thromboplastin time (PTT), are often overlooked in discussions of testing errors.

Purpose of the Study:

To illustrate common errors in laboratory test selection during routine medical practice.
To challenge the assumption that testing errors predominantly occur with rare or genetic tests.
To provide a structured approach for evaluating patients with specific abnormal coagulation profiles.

Main Methods:

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Development of a diagnostic algorithm for patients presenting with a prolonged PTT and normal prothrombin time (PT).
Analysis of clinical scenarios to identify potential pitfalls in test ordering.
Review of current practices in laboratory utilization for common hematological abnormalities.

Main Results:

The study demonstrates that errors in test selection are prevalent even in cases of common abnormalities like prolonged PTT.
The proposed algorithm offers a systematic method to investigate prolonged PTT with normal PT.
Findings suggest a need to re-evaluate educational strategies regarding appropriate laboratory test utilization.

Conclusions:

Diagnostic errors can arise from suboptimal test selection even for routine laboratory findings.
A clear algorithm can aid clinicians in the accurate investigation of prolonged PTT, improving patient care.
Focusing on common abnormalities is essential for improving overall laboratory test utilization and patient safety.