Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Formation by Endochondral Ossification01:24

Bone Formation by Endochondral Ossification

Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
Compact Bone01:27

Compact Bone

Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Outcomes and Complications Rates at Mid-term Follow-Up of Cementless Reverse Shoulder Arthroplasty.

La Tunisie medicale·2026
Same author

Knowledge of osteoporosis prevention among health science students in North Africa: a descriptive correlational cross-sectional study.

Archives of osteoporosis·2026
Same author

Isolated Muscular Echinococcosis of the Hand and Forearm: A Case Report.

Journal of orthopaedic case reports·2024
Same author

Traumatic Shoulder Dislocation in a Child: A Case Report.

Journal of orthopaedic case reports·2024
Same author

Management of Ewing Sarcoma of Distal Fibula in Child: A Case Report.

Journal of orthopaedic case reports·2024
Same author

Osteonecrosis of the Humeral Head Following Arthroscopic Repair of Rotator Cuff Tears: A Case Report.

Journal of orthopaedic case reports·2024

Related Experiment Video

Updated: May 20, 2026

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
06:40

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Published on: October 21, 2015

[Chondroblastoma of bone ].

Mahmoud Ben Maitigue1, Walid Osman, Fatma Ouni

  • 1Faculte de Medecine de Sousse, Universitd de Sousse, Tunisie.

La Tunisie Medicale
|July 20, 2012
PubMed
Summary

Chondroblastoma, a rare bone tumor in young individuals, typically affects long bone epiphyses. Surgical curettage and grafting offer good outcomes, but recurrence risk is linked to aggressive features and incomplete removal.

More Related Videos

Co-localization of Cell Lineage Markers and the Tomato Signal
10:56

Co-localization of Cell Lineage Markers and the Tomato Signal

Published on: December 28, 2016

Related Experiment Videos

Last Updated: May 20, 2026

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage
06:40

Visualization of Chondrocyte Intercalation and Directional Proliferation via Zebrabow Clonal Cell Analysis in the Embryonic Meckel’s Cartilage

Published on: October 21, 2015

Co-localization of Cell Lineage Markers and the Tomato Signal
10:56

Co-localization of Cell Lineage Markers and the Tomato Signal

Published on: December 28, 2016

Area of Science:

  • Orthopedic Oncology
  • Bone Tumors
  • Skeletal Radiology

Context:

  • Chondroblastoma is a rare, benign cartilaginous bone tumor.
  • It predominantly affects adolescents and young adults (10-20 years).
  • Lesions are commonly found in the epiphysis of long bones.

Purpose:

  • To investigate the epidemiological, clinical, and radiological characteristics of chondroblastoma.
  • To evaluate surgical treatment outcomes for chondroblastoma.
  • To identify factors associated with tumor recurrence.

Summary:

  • A retrospective study analyzed 13 chondroblastoma cases (1991-2007).
  • Average patient age was 18.2 years; long bones were most affected.
  • Pain and swelling were primary symptoms; radiographs showed lytic lesions; CT revealed calcifications and soft tissue extension.
  • Surgical management included curettage (11 cases), curettage with grafting (5 cases), and resection (1 case).
  • Two recurrences were observed over an 8-year mean follow-up, with good functional results in 11 cases.

Impact:

  • Curettage and bone grafting are the preferred surgical treatments for chondroblastoma.
  • Prognosis is influenced by recurrence rates, with aggressive features and incomplete curettage being key predictive factors.
  • While plane radiographs suffice for typical cases, MRI aids in unusual presentations.