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Updated: May 20, 2026

Semi-automated Analysis of Mouse Skeletal Muscle Morphology and Fiber-type Composition
Published on: August 31, 2017
Systems biology of skeletal muscle: fiber type as an organizing principle
Sarah M Greising1, Heather M Gransee, Carlos B Mantilla
1Department of Physiology & Biomedical Engineering, Mayo Clinic, Rochester, MN, USA.
Abstract:
Skeletal muscle force generation and contraction are fundamental to countless aspects of human life. The complexity of skeletal muscle physiology is simplified by fiber type classification where differences are observed from neuromuscular transmission to release of intracellular Ca(2+) from the sarcoplasmic reticulum and the resulting recruitment and cycling of cross-bridges. This review uses fiber type classification as an organizing and simplifying principle to explore the complex interactions between the major proteins involved in muscle force generation and contraction.
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