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Emerging therapies in pancreas cancer

Adam Kotowski1, Wen W Ma

  • 1Roswell Park Cancer Institute, Buffalo, NY.

Journal of Gastrointestinal Oncology
|July 20, 2012
PubMed

Insights

Pancreas cancer treatment is limited. Emerging therapies include targeted agents and cytotoxics, with combination regimens showing future promise for improved outcomes.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Pancreas cancer has a poor prognosis with limited treatment options.
  • Advancements in anti-cancer chemotherapeutics have yet to significantly improve outcomes.

Purpose of the Study:

  • To review emerging therapies for pancreas cancer.
  • To focus on novel signal transduction inhibitors and cytotoxics in clinical development.

Main Methods:

  • Review of clinical development data for novel signal transduction inhibitors (insulin-like growth factor receptor, hedgehog/Smo, PI3k/Akt/mTOR).
  • Analysis of emerging cytotoxic agents, including nab-paclitaxel.
  • Evaluation of combination regimens.

Main Results:

  • Molecularly targeted agents show limited efficacy as monotherapy in pancreas cancer.
  • The cytotoxic regimen FOLFIRINOX demonstrated superiority over gemcitabine.
  • Emerging therapies are primarily in clinical development.

Conclusions:

  • The future of pancreas cancer therapy likely involves combination regimens.
  • Combining cytotoxics with molecularly targeted agents may offer improved treatment strategies.
Keywords:
Pancreas cancerchemotherapytarget therapy

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