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Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
[Thoughts and exploration on pharmacokinetic study of herbal medicines based on metabonomics and complex network]
Zheng Xiang1, Xiao-Jun Cai, Su Zeng
1School of Pharmaceutical Sciences, Wenzhou Medical College, Wenzhou 325035, China. XZH007@126.com
Abstract:
The change of drug development pattern pushes the innovation of drug valuation methods. The pharmacokinetic research of traditional Chinese medicines (TCM) is an important part of TCM modernization and plays a key role in novel drug development of TCM. However, the research methods and techniques are in consistent with the specific characteristics of TCM, i.e., multiple-components is still in the infant. This review makes a brief summary of current pharmacokinetic exploration of TCM, metabonomics and complex network, and puts forward a new strategy based on complex network and metabonomics to study TCM pharmacokinetic in order to disclose the active components and mechanism of TCM.
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