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Related Concept Videos

Kidney Structure01:45

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Internal Anatomy of the Kidney01:12

Internal Anatomy of the Kidney

The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Anatomy of the Genitourinary System I: Kidneys and Ureters01:11

Anatomy of the Genitourinary System I: Kidneys and Ureters

The upper urinary system comprises two kidneys and two ureters, which are crucial in filtering blood and forming urine.KidneysLocation and Structure:The kidneys are two bean-shaped organs positioned behind the peritoneum on either side of the spine.Kidneys are between the 12th thoracic (T12) and the 3rd lumbar (L3) vertebrae.The position of the liver causes the right kidney to sit slightly lower than the left.Protective Layers:Each kidney is enveloped in a tough, fibrous membrane called the...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

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20-Year Follow-up of Two Cases of Bilateral Hand Transplantation.

The New England journal of medicine·2020
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Lymphodepletive effects of rabbit anti-pig thymocyte globulin in neonatal swines.

Transplant immunology·2016
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Face graft? Extrapolation of facial allotransplantation to children.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2016
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Chronic Rejection in Human Vascularized Composite Allotransplantation (Hand and Face Recipients): An Update.

Transplantation·2016
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Transplant Tolerance Induction in Newborn Infants: Mechanisms, Advantages, and Potential Strategies.

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Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands).

Case reports in transplantation·2015

Related Experiment Video

Updated: May 20, 2026

Whole-Kidney Three-Dimensional Staining with CUBIC
04:31

Whole-Kidney Three-Dimensional Staining with CUBIC

Published on: July 18, 2022

[The kidney].

Jean-Michel Dubernard1

  • 1Service d'Urologie et Chirurgie de la Transplantation, Pavillon V, Hôpital Edouard Heniot, 69437 Lyon. jean-michel.dubernard@chu-lyon.fr

Bulletin De L'Academie Nationale De Medecine
|July 21, 2012
PubMed
Summary

Whole-organ kidney engineering faces challenges due to complexity. Promising approaches include using extracellular matrix scaffolds and stem cells for recellularization, alongside bioartificial kidney devices.

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nephrology

Context:

  • Kidney organogenesis is complex, involving heterogeneous cell types and intricate structures.
  • Current research focuses on overcoming these challenges for whole-organ kidney engineering.
  • Existing kidney assistance devices, like bioartificial kidneys, show promise in clinical trials.

Purpose:

  • To explore strategies for whole-organ kidney engineering, including scaffold development and cell sources.
  • To investigate the potential of extracellular matrix scaffolds and various stem cell types for kidney recellularization.
  • To review the progress and feasibility of ex-vivo kidney fabrication and bioartificial kidney devices.

Summary:

  • Decellularized kidneys from various species provide extracellular matrix scaffolds preserving vasculature.

More Related Videos

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
03:19

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition

Published on: June 21, 2024

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

Related Experiment Videos

Last Updated: May 20, 2026

Whole-Kidney Three-Dimensional Staining with CUBIC
04:31

Whole-Kidney Three-Dimensional Staining with CUBIC

Published on: July 18, 2022

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
03:19

Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition

Published on: June 21, 2024

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach
09:15

Orthotopic Rat Kidney Transplantation: A Novel and Simplified Surgical Approach

Published on: May 7, 2019

  • Diverse cell sources, including stem cells, are being explored for kidney recellularization.
  • In-vitro reproduction of nephron development and bioartificial kidneys with functional renal cells are key research areas.

    • Impact:

    • Successful whole-organ kidney engineering could offer a solution for chronic renal failure.
    • Advancements in bioartificial kidneys may provide effective renal replacement therapy.
    • Regenerative medicine approaches hold the potential to eliminate transplant rejection risks.