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Related Concept Videos

Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
Anatomy of Respiratory System II: Lower Respiratory Tract01:31

Anatomy of Respiratory System II: Lower Respiratory Tract

The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
The Respiratory System01:16

The Respiratory System

The respiratory system is comprised of the organs that enable breathing. Air enters the nostrils and mouth, followed by the pharynx (throat) and larynx (voice box), which lead to the trachea (windpipe). In the thoracic cavity, the trachea splits into two bronchi that allow air to enter the lungs. The bronchi split into progressively smaller bronchioles and terminate in small groups of tiny sacs in the lungs called alveoli, where gas exchange occurs.
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
Overview of Respiratory System01:23

Overview of Respiratory System

The respiratory system is a complex biological apparatus that facilitates the exchange of gases, specifically oxygen and carbon dioxide, between our bodies and the environment. This system plays a vital role in the physiological process of respiration, an essential function for sustaining life.
What is the Respiratory System?
The respiratory system consists of a series of organs responsible for taking in oxygen and expelling carbon dioxide. The primary function of the respiratory system is to...

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Related Experiment Video

Updated: May 20, 2026

Point-of-Care Lung Ultrasound in Adults: Image Acquisition
09:17

Point-of-Care Lung Ultrasound in Adults: Image Acquisition

Published on: March 3, 2023

[The lung].

Emmanuel Martinod1, Yurdagül Uzunhan, Dana M Radu

  • 1Chirurgie thoracique et vasculaire, Assistance Publique-Hôpitaux de Paris, CHU Paris - Seine Saint Denis, Hôpital Avicenne, Pôle Activités cancérologiques spécialisées, Faculté de Médecine SMBH, Bobigny, Université Paris 13. emmanuel.martinod@avc.aphp.fr

Bulletin De L'Academie Nationale De Medecine
|July 21, 2012
PubMed
Summary
This summary is machine-generated.

Creating a bio-artificial lung using decellularized lung matrices and autologous cells shows promise for treating end-stage lung diseases. This regenerative medicine approach could overcome donor limitations and improve transplant outcomes within two decades.

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Last Updated: May 20, 2026

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Engineering
  • Pulmonary Medicine

Context:

  • Lung transplantation is the sole cure for end-stage pulmonary diseases but faces challenges like donor scarcity and chronic rejection.
  • Current immunosuppressive therapies for lung transplant recipients carry significant risks.
  • Bio-artificial lungs (BALs) engineered from autologous cells offer a potential solution to these limitations.

Purpose:

  • To explore the feasibility of regenerating lung components using decellularized lung matrices and autologous cells.
  • To assess the potential of bio-artificial lungs for functional gas exchange and transplantation.
  • To advance regenerative strategies for end-stage lung disease treatment.

Summary:

  • Research focuses on creating a functional bio-artificial lung using decellularized lung matrices repopulated with autologous cells, including stem cells.
  • Studies demonstrate successful in vivo airway and cartilage regeneration using tissue matrices.
  • Recellularized matrices implanted in animal models have shown functional viability, paving the way for future human applications.

Impact:

  • Successful development of BALs could eliminate donor organ shortages and reduce the need for lifelong immunosuppression.
  • This regenerative approach holds the potential to revolutionize treatment for chronic lung diseases.
  • Human transplantation of bio-artificial lungs is anticipated within the next 10-20 years.