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Updated: May 20, 2026

Preparation of Quality Inositol Pyrophosphates
Published on: September 3, 2011
[Preparation and quality control of pyridostigmine bromide orally disintegrating tablet]
Li Zhang1, Qun-you Tan, Xun-guan Cheng
1Medicine Engineering Research Center in University, Chongqing Key Laboratory of Biochemical & Molecular Pharmacology, Chongqing Medical University, Chongqing 400016, China.
Objective:
To prepare orally disintegrating tablets containing pyridostigmine bromide and optimize formulations.
Methods:
Solid dispersion was prepared using solvent evaporation-deposition method. The formulation was optimized by central composite design-response surface methodology (RSM plus CCD) with disintegration time as a reference parameter.
Results:
The orally disintegrating tablets showed integrity and were smooth with desirable taste and feel in mouth. The disintegration time was less than 30 s. The cumulative drug dissolution was around 8.5% (around 2.5 mg which was less than bitterness threshold of pyridostigmine bromide of 3 mg) within 5 min in water while the cumulative drug dissolution was higher than 95% within 2 min in 0.1 N HCl.
Conclusion:
The orally disintegrating tablets are reasonable in formulation, feasible in technology and patient-friendly.
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