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Published on: December 13, 2019
[Left ventricular diastolic function of patients with newly diagnosed hyperthyroidism]
Xian-Chao Jing1, Yang Liu, Hui Huang
1Department of Cardiology, West China Hospital, Sichuan University ,Chengdu 610041,China.
Summary
Newly diagnosed hyperthyroidism impairs left ventricular diastolic function. Advanced echocardiography techniques, including pulmonary venous flow and Tissue Doppler imaging, are more sensitive for detecting this diastolic dysfunction than conventional methods.
Area of Science:
- Cardiology
- Internal Medicine
- Medical Diagnostics
Background:
- Hyperthyroidism is a common endocrine disorder.
- Left ventricular diastolic dysfunction (LVDD) can be an early manifestation of cardiovascular changes in hyperthyroidism.
Purpose of the Study:
- To evaluate left ventricular diastolic function in patients with newly diagnosed hyperthyroidism.
- To compare the sensitivity of conventional echocardiography with advanced techniques for assessing LVDD in hyperthyroidism.
Main Methods:
- Echocardiography was used to assess left ventricular diastolic function in 43 hyperthyroid patients and 45 controls.
- Techniques included mitral inflow, Valsalva maneuver, pulmonary venous flow, Tissue Doppler imaging, and Left atrial volume index (LAVI).
Main Results:
- Hyperthyroid patients exhibited higher heart rate and ejection fraction but no significant difference in LAVI compared to controls.
- Significant differences were observed in Valsalva maneuver parameters (E'/A'), A duration, pulmonary venous flow characteristics (D, Ar, Ar duration, Ar-A duration), S/D ratio, and Tissue Doppler indices (Em/Am, E/Em).
- These findings indicate impaired diastolic function in hyperthyroid patients.
Conclusions:
- Newly diagnosed hyperthyroidism is associated with impaired left ventricular diastolic function.
- Combining pulmonary venous flow, Tissue Doppler imaging, and mitral inflow during Valsalva maneuver offers superior sensitivity for diagnosing diastolic dysfunction compared to conventional Doppler echocardiography.
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