Related Experiment Video

Updated: May 20, 2026

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats
08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

[Left ventricular diastolic function of patients with newly diagnosed hyperthyroidism]

Xian-Chao Jing1, Yang Liu, Hui Huang

  • 1Department of Cardiology, West China Hospital, Sichuan University ,Chengdu 610041,China.

Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition
|July 21, 2012
PubMed

Insights

Newly diagnosed hyperthyroidism impairs left ventricular diastolic function. Advanced echocardiography techniques, including pulmonary venous flow and Tissue Doppler imaging, are more sensitive for detecting this diastolic dysfunction than conventional methods.

Area of Science:

  • Cardiology
  • Internal Medicine
  • Medical Diagnostics

Background:

  • Hyperthyroidism is a common endocrine disorder.
  • Left ventricular diastolic dysfunction (LVDD) can be an early manifestation of cardiovascular changes in hyperthyroidism.

Purpose of the Study:

  • To evaluate left ventricular diastolic function in patients with newly diagnosed hyperthyroidism.
  • To compare the sensitivity of conventional echocardiography with advanced techniques for assessing LVDD in hyperthyroidism.

Main Methods:

  • Echocardiography was used to assess left ventricular diastolic function in 43 hyperthyroid patients and 45 controls.
  • Techniques included mitral inflow, Valsalva maneuver, pulmonary venous flow, Tissue Doppler imaging, and Left atrial volume index (LAVI).

Main Results:

  • Hyperthyroid patients exhibited higher heart rate and ejection fraction but no significant difference in LAVI compared to controls.
  • Significant differences were observed in Valsalva maneuver parameters (E'/A'), A duration, pulmonary venous flow characteristics (D, Ar, Ar duration, Ar-A duration), S/D ratio, and Tissue Doppler indices (Em/Am, E/Em).
  • These findings indicate impaired diastolic function in hyperthyroid patients.

Conclusions:

  • Newly diagnosed hyperthyroidism is associated with impaired left ventricular diastolic function.
  • Combining pulmonary venous flow, Tissue Doppler imaging, and mitral inflow during Valsalva maneuver offers superior sensitivity for diagnosing diastolic dysfunction compared to conventional Doppler echocardiography.
Abstract

More Related Videos

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs08:19

Transthoracic Echocardiography to Assess Post-Resuscitation Left Ventricular Dysfunction After Acute Myocardial Infarction and Cardiac Arrest in Pigs

Published on: July 12, 2022

Related Concept Videos

Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...