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Risk factors for suicide behaviors in the observational schizophrenia outpatient health outcomes (SOHO) study
Roberto Brugnoli1, Diego Novick, Josep Maria Haro
1Italian Foundation for the study of Schizophrenia, Rome, Italy.
Background:
To identify risk factors for suicide using data from a large, 3-year, multinational follow-up study of schizophrenia (SOHO study).
Methods:
Baseline characteristics of 8,871 adult patients with schizophrenia were included in a logistic regression post-hoc analysis comparing patients who attempted and/or committed suicide during the study with those who did not.
Results:
384 (4.3%) patients attempted or committed suicide. Completed suicides were 27 (0.3%). The significant risk factors for suicide behaviors were previous suicidality, depressive symptoms, prolactin-related adverse events, male gender and history of hospitalization for schizophrenia.
Conclusions:
In view of the observational design of the study and the post-hoc nature of the analysis, the identified risk factors should be confirmed by ad-hoc specifically designed studies.
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