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Esophageal Strictures-II: Clinical Features and Management01:26

Esophageal Strictures-II: Clinical Features and Management

Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Trachea01:22

Trachea

The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of the...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Pyloric Obstruction01:11

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Pyloric obstruction, also referred to as gastric outlet obstruction, is a condition characterized by narrowing or blockage at the pylorus—the muscular valve regulating the flow of stomach contents into the duodenum. When this passage becomes impaired, the stomach cannot effectively empty its contents into the small intestine. This disruption leads to a range of gastrointestinal symptoms, including early satiety, bloating, epigastric pain, postprandial nausea, persistent vomiting, and...

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Related Experiment Video

Updated: May 20, 2026

Robotic Myotomy and Partial Fundoplication for Achalasia
11:19

Robotic Myotomy and Partial Fundoplication for Achalasia

Published on: August 11, 2023

Fundoplication in chronic intractable cough.

Shoaib Faruqi1, Peter Sedman, Warren Jackson

  • 1Department of Cardiovascular and Respiratory Studies, Castle Hill Hospital, Hull York Medical School, University of Hull, Cottingham, HU16 5JQ, UK. sfaruqi@doctors.net.uk.

Cough (London, England)
|July 21, 2012
PubMed
Summary

Nissen fundoplication offers a useful treatment option for chronic cough refractory to medical therapy, with a 63% long-term response rate. However, treatment failure may be linked to persistent gaseous reflux.

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Area of Science:

  • Gastroenterology
  • Pulmonology
  • Surgical Therapy

Background:

  • Airway reflux frequently causes chronic cough, often resistant to medical treatments.
  • Nissen fundoplication effectively manages classic gastroesophageal reflux disease symptoms like heartburn and dyspepsia.
  • Limited data exists on fundoplication's efficacy for chronic cough as the primary symptom.

Purpose of the Study:

  • To evaluate the effectiveness of Nissen fundoplication in patients with chronic cough.
  • To assess the long-term outcomes and complications of fundoplication for refractory chronic cough.

Main Methods:

  • Retrospective review of 47 patients undergoing Nissen fundoplication for chronic cough.
  • Data collected included demographics, symptom duration, associated symptoms, esophageal study results, and outcomes.
  • Post-operative questionnaires and pharyngeal pH monitoring in a subgroup assessed treatment response.

Main Results:

  • The average duration of pre-operative cough was 8 years.
  • 64% of patients experienced a positive response to Nissen fundoplication.
  • Common post-operative issues included mild dysphagia and bloating; 63% long-term response rate observed.

Conclusions:

  • Nissen fundoplication is a viable therapeutic option for intractable chronic cough, achieving a 63% response rate.
  • Failure rates may be higher than for typical reflux symptoms, potentially due to persistent gaseous reflux.
  • Further investigation into the mechanisms of treatment failure is warranted.