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Breath Collection from Children for Disease Biomarker Discovery

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Online sample conditioning for portable breath analyzers.

Amlendu Prabhakar¹, Rodrigo A Iglesias, Xiaonan Shan

¹Center for Bioelectronics & Biosensors, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, USA.

Analytical Chemistry

|July 21, 2012

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A new miniaturized mouthpiece effectively conditions breath samples by reducing humidity while preserving crucial biomarker concentrations. This innovation enhances the accuracy of personal breath analyzers for real-world applications.

Area of Science:

Chemical sensing
Biomarker detection
Sensor technology

Background:

Innovative chemical sensors are vital for detecting airborne hazards and breath biomarkers.
Efficient sample conditioning, particularly humidity control, is crucial for real-world sensor applications but is under-addressed in research.
Personal breath analyzers require effective methods for sample preparation.

Purpose of the Study:

To develop a miniaturized mouthpiece for personal breath analyzers that conditions humidity in breath samples.
To ensure the mouthpiece maintains analyte concentrations and avoids significant backpressure.
To optimize the desiccant particle packing for effective humidity control.

Main Methods:

Numerical simulations were employed to analyze mouthpiece performance based on packing parameters (size, density, geometry).

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Mouthpiece prototypes with varying configurations were constructed and experimentally tested.

Experimental results were compared with simulation findings for validation.

Main Results:

The optimized mouthpiece significantly reduced relative humidity from 95% to 29% (27,000 ppmV to 8000 ppmV).
Nitric oxide (NO) concentrations were well-preserved, with 92% retention (50 ppbV to 46 ppbV).
Integration into a hand-held exhaled NO sensor showed good agreement with the gold standard chemiluminescence technique.

Conclusions:

The developed desiccant mouthpiece provides effective breath sample conditioning for personal breath analyzers.
The approach demonstrates wide applicability, validated by testing with various gases (acetone, CO2, O2, ammonia).
This technology improves the reliability and accuracy of breath analysis for health monitoring and diagnostics.