Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Construction of a 3D printed, human gingival MSC seeded alveolar bone implant.

Journal of applied biomaterials & functional materials·2026
Same author

Modeling a hypoxia-integrated glioblastoma microenvironment to mimic tumor heterogeneity and chemoresistance.

Biomaterials science·2026
Same author

Development of a tissue-engineered oral mucosal barrier model using poly (L-lactic acid) electrospun nanofibers.

Scientific reports·2026
Same author

Single-nucleus ATAC-seq analysis resolves chromatin and transcriptional features of fibrolamellar carcinoma.

Scientific reports·2026
Same author

Nerve tissue model on a micropatterned surface: Axon guidance and neural regeneration.

Journal of materials science. Materials in medicine·2025
Same author

Hepatic adaptation to chronic metabolic stress primes tumorigenesis.

Cell·2025

Related Experiment Video

Updated: May 20, 2026

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates
07:19

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates

Published on: March 7, 2014

Understanding the cell behavior on nano-/micro-patterned surfaces.

Vasif Hasirci1, Brian J Pepe-Mooney

  • 1Middle East Technical University, Biotechnology Research Unit, Ankara 06531, Turkey. vhasirci@metu.edu.tr

Nanomedicine (London, England)
|July 21, 2012
PubMed
Summary
This summary is machine-generated.

Cell type and surface topography significantly influence cell alignment on patterned substrates, more than surface chemistry. This finding is crucial for designing effective tissue engineering scaffolds and implants.

More Related Videos

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior
09:06

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Published on: December 8, 2016

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Related Experiment Videos

Last Updated: May 20, 2026

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates
07:19

Cell Patterning on Photolithographically Defined Parylene-C: SiO2 Substrates

Published on: March 7, 2014

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior
09:06

Expanding Nanopatterned Substrates Using Stitch Technique for Nanotopographical Modulation of Cell Behavior

Published on: December 8, 2016

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level
11:14

A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)–Cell Interaction and the Resultant Bioeffects at the Single-cell Level

Published on: January 10, 2017

Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Tissue Engineering

Background:

  • Investigating cell-substrate interactions is key for developing advanced biomedical materials.
  • Understanding how physical and chemical surface properties influence cell behavior is critical for regenerative medicine.

Purpose of the Study:

  • To examine the interactions between various cell types and patterned substrates with differing dimensions and chemistries.
  • To determine the relative importance of cell type, surface topography, and surface chemistry on cell alignment.

Main Methods:

  • Tested multiple cell types including bone marrow stromal cells, retinal pigment epithelial cells, and Saos-2 cells.
  • Utilized surfaces with varied physical patterns (microgrooves) and chemical properties.
  • Assessed cell responses to different substrate parameters.

Main Results:

  • Cell type and surface topography were found to be more influential than surface chemistry in dictating cell alignment.
  • Low-height walls (microns) did not confine cells into microgrooves but alignment occurred if cells possessed inherent alignment properties.

Conclusions:

  • Findings provide valuable insights for the design of tissue engineering scaffolds.
  • This research aids in improving the long-term success of medical implants through optimized surface design.