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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

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Related Experiment Video

Updated: May 20, 2026

Orthotopic Hind Limb Transplantation in the Mouse
07:15

Orthotopic Hind Limb Transplantation in the Mouse

Published on: February 12, 2016

Chain transplantation: initial experience of a large multicenter program.

M L Melcher1, D B Leeser, H A Gritsch

  • 1Department of Surgery, Stanford University, CA, USA. melcherm@stanford.edu

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|July 21, 2012
PubMed
Summary
This summary is machine-generated.

Chain transplantation, using a multicenter database, successfully facilitated 272 kidney transplants from incompatible donor/recipient pairs. This innovative approach significantly increased transplant access, especially for minority recipients.

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Area of Science:

  • Nephrology
  • Transplantation immunology
  • Medical informatics

Background:

  • Kidney transplantation is limited by donor-recipient immunological incompatibility.
  • Nondirected donor kidney paired donation programs offer a solution but can be complex to manage.
  • Multicenter collaboration is essential for large-scale paired donation initiatives.

Purpose of the Study:

  • To evaluate the effectiveness of chain transplantation facilitated by a multicenter US database.
  • To assess the outcomes of kidney transplants performed through chain donation pathways.
  • To determine the impact of chain transplantation on access to organs for diverse patient populations.

Main Methods:

  • A multicenter US database was utilized to pool incompatible donor/recipient pairs.
  • A computer algorithm incorporating virtual cross-matches identified potential chains initiated by nondirected donors.
  • Chains were tracked, and transplant outcomes, including graft function and patient demographics, were analyzed.

Main Results:

  • The first 54 chains facilitated 272 kidney transplants with a mean chain length of 5.0.
  • All recipients whose intended donors donated received a transplant; seven chains ended prematurely.
  • 46% of recipients were ethnic minorities, and 63% of grafts were shipped between centers. Blood type O recipients (n=90) exceeded O donors (n=32).
  • The first 100 transplants showed a mean 1-year creatinine of 1.3 mg/dL.

Conclusions:

  • Chain transplantation effectively overcomes immunological barriers in kidney donation.
  • This multicenter approach significantly expands transplant opportunities for recipients with incompatible donors.
  • Chain transplantation demonstrates a high success rate with good graft function and improved access for minority populations.