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Updated: May 20, 2026

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
Published on: October 6, 2015
Immunisation status and its predictors among children of HIV-infected people in Kolkata
Pinaki Sensarma1, Subhasis Bhandari, V Raman Kutty
1Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
Insights
This study found that 73% of children exposed to HIV in Kolkata were fully immunized by 12 months, similar to the general population. Key predictors for complete immunization included maternal antenatal care and education.
Area of Science:
- Public Health
- Pediatrics
- Epidemiology
Background:
- Universal immunisation programs are recommended by WHO and UNICEF for diseases like tuberculosis, polio, and measles.
- Information on immunisation coverage for HIV-exposed children in India is limited.
- The study addresses a critical gap in understanding child health outcomes within vulnerable populations.
Purpose of the Study:
- To determine the proportion of HIV-exposed children fully immunised by 12 months in Kolkata.
- To identify predictors associated with complete immunisation in this population.
- To inform targeted interventions for improving child immunisation rates.
Main Methods:
- A community-based cross-sectional survey was conducted in the Kolkata Metropolitan Area.
- Data were collected from 256 caregivers of HIV-exposed children using a pre-structured interview schedule.
- Multiple logistic regression analysis was employed to identify significant predictors of complete immunisation.
Main Results:
- 73.0% of HIV-exposed children achieved complete immunisation by 12 months, a rate comparable to the general child population.
- Maternal antenatal care, maternal post-primary education, and child's religion (Hindu/Christian) were significant predictors.
- Children not belonging to scheduled castes, tribes, or other backward classes also showed higher complete immunisation rates.
Conclusions:
- Antenatal care and maternal education are crucial for ensuring complete child immunisation.
- Targeted efforts are needed to improve immunisation coverage among Muslim communities and socially disadvantaged groups.
- Empowering women through education can lead to long-term improvements in child health outcomes.
Abstract:
World Health Organization and United Nations International Children's Emergency Fund have strongly recommended a sustained coverage of universal immunisation among all children against tuberculosis, polio, diphtheria, pertussis, tetanus and measles. In India, these vaccines under the universal immunisation programme are made available absolutely free of cost to all children through the public health system. Information regarding immunisation coverage among HIV exposed children in India is still very limited. The objective of this study was to estimate the proportion of children of people living with HIV who had been completely immunised by the age of 12 months and to find predictors of complete immunisation. A community-based cross-sectional survey was conducted in the Kolkata Metropolitan Area between 15 June and 14 September 2009 using a pre-structured interview schedule. Data were analysed from 256 care-givers of children (85.5% response rate) whose parents were randomly selected from the Bengal Network of HIV-positive people. Multiple logistic regression was used to estimate and test associations of predictors with complete immunisation. The percentage of children of people living with HIV completely immunised at the age of 12 months was 73.0% (67.3% to 78.1%), which was not significantly different from that for all children at 12 months. Mothers having received antenatal care [OR (odds ratio): 7.29; 95% confidence intervals (CI): 2.39-22.25], mothers having postprimary education (OR: 3.37; 95% CI: 1.45-7.81), children of Hindu and Christian religion (OR: 3.74; 95% CI: 1.63-8.62), children not belonging to scheduled castes, tribes and 'other backward classes' (OR: 2.08; 95% CI: 1.02-4.25) were significant independent predictors of complete immunisation status of these children. This emphasises the imperative need for up-scaling of antenatal care among the pregnant mothers to ensure complete immunisation among their children. A special focus on girl child education should also be implemented to empower future mothers for a sustained improvement of child immunisation in the long-run. The current national immunisation programme should focus on the children from the Muslim community and those belonging to scheduled castes, tribes and other backward classes to improve coverage.
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