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Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
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Tissue-engineered devices in cardiovascular surgery.

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  • 1Reference and Translation Center for Cardiac Stem Cell Therapy, University of Rostock, Rostock, Germany.

European Surgical Research. Europaische Chirurgische Forschung. Recherches Chirurgicales Europeennes
|July 21, 2012
PubMed
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Tissue engineering (TE) aims to create ideal, lifelong cardiovascular implants. Current research focuses on developing tissue-engineered myocardial, valvular, and vascular devices, with decellularized scaffolds showing promise for improved patient outcomes.

Area of Science:

  • Cardiovascular research
  • Biomaterials science
  • Regenerative medicine

Background:

  • The development of lifelong functional cardiovascular (CV) implants is a major goal in cardiothoracic research.
  • Current artificial CV implants have limitations, including intimal hyperplasia, antigenicity, and thrombogenicity.
  • Tissue engineering (TE) offers a promising approach to create vital, growing, and adaptive CV prostheses.

Purpose of the Study:

  • To review the state-of-the-art in TE techniques for cardiovascular products.
  • To describe milestones in the development of tissue-engineered myocardial, valvular, and vascular devices.
  • To discuss experimental and clinical perspectives on TE for CV applications.

Main Methods:

  • Review of current literature on tissue engineering for cardiovascular devices.

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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
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Related Experiment Videos

Last Updated: May 20, 2026

Generation and Grafting of Tissue-engineered Vessels in a Mouse Model
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Published on: March 18, 2015

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method
09:38

Scaling of Engineered Vascular Grafts Using 3D Printed Guides and the Ring Stacking Method

Published on: March 27, 2017

Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber
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Tissue Engineering by Intrinsic Vascularization in an In Vivo Tissue Engineering Chamber

Published on: May 30, 2016

  • Analysis of experimental and clinical data on myocardial, valvular, and vascular TE.
  • Evaluation of advancements in scaffold design, cellularization, and surface modification.

    • Main Results:

    • Initial clinical trials for TE cardiovascular devices have commenced.
    • Decellularized allogeneic bioprostheses are promising scaffolds for autologous cellularization.
    • In vitro endothelialization is emerging as a key factor for long-term success of biological TE grafts.

    Conclusions:

    • Tissue engineering holds significant potential for creating superior cardiovascular implants.
    • Decellularized matrices and in vitro endothelialization represent key advancements.
    • Continued research and clinical translation are crucial for realizing the full potential of TE in CV medicine.