[A comparative evaluation of the efficacy of treatment methods in chronic glomerulonephritis]

The results of the treatment of 498 patients with chronic glomerulonephritis (CGN) verified on biopsy were analyzed to reveal that all the types of therapy were less effective in episodes of the nephrotic syndrome and frequent relapses than in rarer exacerbations and the lack of massive proteinuria. Considerable differences in the survival of patients with varying activity of CGN treated in the same way attest to the limited possibilities of the pathogenetic and symptomatic agents as regards their action on the natural disease course. The treatment with glucocorticoids, cytostatics and the combined use of these drugs turned out more successful provided the time of the drugs intake was increased to 1-2 years. Administration of glucocorticoids and the long-term use of cytostatics in cases of the sensitivity to them of mononuclear receptors appeared most effective in all the clinical manifestations of mesangioproliferative, membranous proliferative or membranous glomerulonephritis.