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Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

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Related Experiment Video

Updated: May 20, 2026

A Murine Model of Carotid Aneurysm Formation
03:47

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

MicroRNAs and aneurysm formation.

Reinier A Boon1, Stefanie Dimmeler

  • 1Institute of Cardiovascular Regeneration, Center for Molecular Medicine, Goethe University, 60596 Frankfurt, Germany.

Trends in Cardiovascular Medicine
|July 21, 2012
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRs) are involved in aneurysm formation. Inhibiting miR-29 in mice reduced aneurysm development, suggesting potential therapeutic applications for miR-29 inhibitors in treating arterial aneurysms.

More Related Videos

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Related Experiment Videos

Last Updated: May 20, 2026

A Murine Model of Carotid Aneurysm Formation
03:47

A Murine Model of Carotid Aneurysm Formation

Published on: September 9, 2025

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
08:22

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization

Published on: September 15, 2018

Area of Science:

  • Vascular Biology
  • Molecular Medicine
  • Genetics

Background:

  • Aneurysms involve pathological widening and thinning of arterial walls.
  • MicroRNAs (miRs) are key gene regulators implicated in aneurysm development.
  • Specific miRs like miR-21, miR-26, and miR-143/145 have been linked to aneurysms.

Purpose of the Study:

  • To review the role of miR-29 in aneurysm formation.
  • To explore upstream regulation and downstream targets of miR-29.
  • To discuss the clinical potential of miR-29 inhibitors and other relevant miRs.

Main Methods:

  • Review of recent studies on microRNA involvement in aneurysm pathogenesis.
  • Analysis of miR-29's post-transcriptional repression of extracellular matrix proteins.
  • Examination of experimental data on anti-miR-29 therapy in mouse models.

Main Results:

  • miR-29 plays a role in aneurysm formation by regulating extracellular matrix proteins.
  • Therapeutic inhibition of miR-29 using anti-miRs demonstrated efficacy in reducing experimental aneurysms in mice.
  • Several other miRs are also implicated in the development of arterial aneurysms.

Conclusions:

  • miR-29 is a significant factor in aneurysm pathogenesis.
  • Inhibitors targeting miR-29 show promise as a potential therapy for aneurysms.
  • Further research into miR-29 regulation and other miRs is warranted for clinical translation.